The building was originally attached to the Casa Grande de San Francisco convent, which originally occupied the entire area of Plaza Nueva and its adjacent blocks. The works began around 1527, coinciding with the stay of Emperor Charles V in the city to celebrate his marriage to Isabel of Portugal. Throughout the century, different architects succeeded one another in directing the works, such as Diego de Riaño, Juan Sánchez, Hernán Ruiz II or Benvenuto Tortello.
In the 19th century, following the disappearance of the San Francisco convent, the building was significantly expanded. It was then that the neoclassical façade facing Plaza Nueva was built, the work of Balbino Marrón (1861) and the extension of the façade towards Plaza de San Francisco, directed by Demetrio de los Ríos (1868).
Towards the outside, the exquisite Plateresque decoration of the part built in the 16th century stands out. We can see a complex iconographic program, full of mythological characters and references to Roman antiquity, mixed with the emblems of Carlos V. In this way, it was intended to exalt the city's past, relating it to the glorification of the figure of the emperor . In this way, the aim was to consolidate Seville as the most important city of that great empire that took shape during the 16th century.
On both sides of the arch that originally gave access to the Convent of San Francisco we see two niches with the figures of Hercules and Julius Caesar. Both characters are considered the mythological and historical founders of the city. The sculptures were added in 1854 one of the extensive restorations undertaken on the building's façade. They are the work of Vicente Hernández Couquet.